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Bulletin from the Dept of pharmacy practice-Ashifa college of pharmacy
CEFOPERAZONE
SULBACTAM INJECTION ASSOCIATED RASHES IN A BABY
We report a case on rashes following the
administration of cefoperazone sulbactam for neonatal sepsis in a 5 days old,
female baby
A 5 days old female
baby weighing 2.75kg was admitted to peadiatric unit for presenting with
lethargy and poor sucking for 3 days. On examination, the patient was shown to
be febrile due to fever post vaccination. The laboratory test reports of urine
microscopy showed presence of puss cells in urine rating to 4-6/hpf, RBCs to
10-12/hpf and epithelial cells 30-35/hpf. The SGPT and SGOT values were 22 IU/L
and 68 IU/L respectively. The total bilirubin was 3.9mg/dl. The total leucocyte
was found to be 8700 cells/cu mm and ESR of 5 mm/hr. she was prescribed with
cefoperazone- sulbactam injection 100mg every 8th hourly, syrup
Flora BC three times daily. Cefoperazone sulbactam is an antimicrobial agent
which belongs to third generation cephalosporins used to treat bacterial
septicemia caused by susceptible organisms. Cefoperazone is administered
parenterally. On the days of therapy she
developed maculopapular rashes on the IV injection site on her right foot. This
is suspected to be the adverse reaction of cefoperazone as it has a very high
incident rate. The drug was not withdrawn and fusidic acid was prescribed for
topical application.
The causality of the
event assessed as per WHO-UMC system for standard case causality assessment
criteria can be considered as probable. Analyzed by the Naranjo’s ADR
probability scale, the score was 5, which also make it a probable adverse drug
reaction.
REFERENCE:
1. B.D
Miglani, K G Ravikumar, A textbook of Pharmacy Practice, first edition, page
250-1.
2. K
D Tripathi, Essentials of medical pharmacology, fifth edition, page 663-6.
3. Joseph
T Dipiro, Pharmacist Drug Handbook, page 247-9
Linu
Mohan,Asst prof
Danisha,Ist Mpharm
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