A New topical treatment for psoriasis

Targeting Genetic Abnormalities In Deeper Layers Of The Skin

A New topical treatment for psoriasis

Psoriasis is a chronic autoimmune skin disorder that significantly impacts a patient’s quality of life. The overactive immune system triggers skin cells to grow rapidly and then form psoriatic plaques. The new topical treatment is by targeting genetic abnormalities in deeper layers of the skin. A combination anti-psoriasis therapy has potential for superior and longer-lasting therapeutic effects than current topical treatments.

Researchers based at the Florida Agricultural and Mechanical University have developed a topical formulation of a gene-regulating nanoparticle. The particle carries two nucleic acids, which controls the skin cells from developing psoriatic plaques and suppresses inflammation.

To test the effectiveness of the new formulation, the research team used the Psoriasis Area and Severity Index (PASI), a clinical scoring system from 0–4, with four being the most severe. Before treatment, the psoriatic plaque-like mouse model had a score of four, with increased inflammation and skin thickening, which confirmed their impaired natural healing. The PASI score decreased to zero after five days of the new treatment.

The next stage of the research is to test in humanized mouse models with psoriasis plaque and conduct toxicology tests. From this, if the tests continue to be successful, human trials will be considered.

Reference: http://www.digitaljournal.com/article/362223

Jasim sabith

Sr.Lecturer

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