CEFOPERAZONE SULBACTAM INJECTION ASSOCIATED RASHES IN A BABY

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Quarterly Bulletin from the Dept of pharmacy practice-Ashifa college of pharmacy

CEFOPERAZONE SULBACTAM INJECTION ASSOCIATED RASHES IN A BABY

We report a case on rashes following the administration of cefoperazone sulbactam for neonatal sepsis in a 5 days old, female baby

A 5 days old female baby weighing 2.75kg was admitted to peadiatric unit for presenting with lethargy and poor sucking for 3 days. On examination, the patient was shown to be febrile due to fever post vaccination. The laboratory test reports of urine microscopy showed presence of puss cells in urine rating to 4-6/hpf, RBCs to 10-12/hpf and epithelial cells 30-35/hpf. The SGPT and SGOT values were 22 IU/L and 68 IU/L respectively. The total bilirubin was 3.9mg/dl. The total leucocyte was found to be 8700 cells/cu mm and ESR of 5 mm/hr. she was prescribed with cefoperazone- sulbactam injection 100mg every 8^th hourly, syrup Flora BC three times daily. Cefoperazone sulbactam is an antimicrobial agent which belongs to third generation cephalosporins used to treat bacterial septicemia caused by susceptible organisms. Cefoperazone is administered parenterally.  On the days of therapy she developed maculopapular rashes on the IV injection site on her right foot. This is suspected to be the adverse reaction of cefoperazone as it has a very high incident rate. The drug was not withdrawn and fusidic acid was prescribed for topical application.

The causality of the event assessed as per WHO-UMC system for standard case causality assessment criteria can be considered as probable. Analyzed by the Naranjo’s ADR probability scale, the score was 5, which also make it a probable adverse drug reaction.

REFERENCE:

1.      B.D Miglani, K G Ravikumar, A textbook of Pharmacy Practice, first edition, page 250-1.

2.      K D Tripathi, Essentials of medical pharmacology, fifth edition, page 663-6.

3.      Joseph T Dipiro, Pharmacist Drug Handbook, page 247-9

Linu Mohan,Asst prof

Danisha,Ist Mpharm